According to our Neuroscience Advisor, Clive Hyland, it is possible to see the parallels between rooms in the Caplor House model and the four main areas of the brain:
Activity in the Kitchen parallels the basal system, the region of instincts
Activity in the Family Room parallels the limbic system, the region of feelings
Activity in the Library parallels the cortex, the region of thinking
Activity in the Observatory parallels the prefrontal cortex, the region of purpose and meaning.